PV loop simulator closed-loop time-varying elastance model

Preset

The bar under each slideris the normal range, and the tick is the normal value. Values outside the range are flagged.

Applied to the current state, cumulative

Each press nudges the parameters the drug acts on. Hold a loop first so the class can see the before and after.

ESPVR EDPVR Ea (arterial elastance) Valve events Lock axes

Hemodynamics

Hold a loop to show it here for comparison.

Red marks a value outside its normal range, with an arrow for the direction; hover a value to see the range. Model after Burkhoff & Tyberg (Am J Physiol 1993), as in Harvi: four chambers with time-varying elastance and exponential EDPVRs, systemic and pulmonary arterial and venous compartments, resistive valves with independent forward and regurgitant resistances, optional pericardium. Each change is integrated to a new steady state, so preload, afterload and filling pressures respond together rather than being set independently.