Cath Lab Playbook
1. Before the case
- Indication, and the question the cath needs to answer
- Creatinine and eGFR (sets the contrast limit), potassium, hemoglobin, platelets
- Anticoagulation: warfarin (check INR) or a DOAC (time of last dose)
- Allergies, especially contrast, and whether premedication was given
- Prior caths: access used, catheters that engaged, difficult anatomy
- Prior CABG: which grafts and where they arise. A LIMA usually means left radial or femoral access.
- Dialysis fistula or planned fistula in an arm: do not use that arm
- Radial and femoral pulses, checked yourself
2. Set up your table and manifold
Lay out your table

Lay out the table so you can find things without looking:
- A bowl of heparinized saline, for flushing and keeping wires and catheters wet
- Wet Telfa or gauze, for wiping the wire every time it comes out
- A wire bowl or hoop, for the coiled wire between uses
- A waste bowl for aspirated blood, never the saline bowl
- 10 and 20 mL syringes
Learn the manifold
| Stopcock points | Connects | Used for |
|---|---|---|
| Right | Catheter to syringe; side line cut off | Injecting, aspirating, passing through to the next port |
| Down | Side line to the catheter; syringe cut off | Port 1 at home: the transducer reads the catheter |
| Up | Side line to the syringe; catheter cut off | Drawing saline or contrast, pushing to waste, priming |
| Left | All three open | Not used |
Draw saline / push out waste: down, up, right (ports 1, 2, 3).
Draw contrast: down, right, up (ports 1, 2, 3).
Flush transducer (once): up, right, right (ports 1, 2, 3) + transducer stopcock up (open to air).
Zero transducer (once): right, right, right (ports 1, 2, 3) + transducer stopcock up (open to air).
Inject: right, right, right. Straight from the syringe to the catheter.
Prep the manifold
Out of the packet, every line is full of air. Before the manifold touches a catheter it must hold only saline and contrast, with no bubbles.
- Hang the saline bag, the contrast bottle and the waste bag. Squeeze and release the contrast controller until it holds contrast.
- Saline line: port 2 up, port 3 right. Pull: air comes first, then saline. Push it all into the waste bag. Repeat until the syringe fills with bubble-free saline.
- Contrast line: port 3 up, pull until contrast comes without air. Then port 3 right, port 2 up, and push it to waste.
- Flush transducer: draw bubble-free saline (port 2 up, pull, then port 2 right). Transducer stopcock up (open to air), port 1 up. Push gently until saline drips from the top with no bubbles. Transducer stopcock back to right.
- Flush through the front end of the manifold: right, right, right. Hold the syringe tip down and push saline until it drips out with no bubbles.
- Home: down, right, right. The manifold is primed and waits for the catheter.
Connecting the catheter and zeroing the transducer come once the catheter is in the aorta: section 5.
SimulatorPractice: prep the manifold
Starts fresh from the packet, at home position, every line full of air (white dashes). Work through the prep. The controls below the drawing are laid out like the manifold; with Show next step ticked (at the bottom), the control you need next glows.
3. Access
Pick one. From here through section 8 the guide shows only that access's steps and sizes. Until you pick, both are shown, tagged.
Wires are sized by diameter in inches: 0.014 (coronary), 0.018 and 0.021 (access), 0.035 and 0.038 (the workhorse J-wire). Each wire must fit through the needle or catheter it goes through.
Catheters and sheaths are sized in French: 1 French is 1/3 mm. A catheter's French is its outer diameter (6 French is 2 mm); a sheath's French is the largest catheter it takes.
Sedation and pain relief
Watch the oxygen saturation, breathing and blood pressure on the monitor. The reversal drugs are naloxone (for fentanyl) and flumazenil (for midazolam).
Radial3A. Radial access

Local anaesthetic
Find the strongest pulse, 1 to 2 cm proximal to the radial styloid. With a small needle (25 gauge) raise a small wheal of 1% lidocaine in the skin right over it, 1 to 2 mL. Keep it small: a big bleb flattens the pulse you are about to aim for. Some attendings give it after a first look with ultrasound.
Needle into the artery
Arm on the board, wrist slightly extended, prepped and draped. Find the strongest pulse, 1 to 2 cm proximal to the radial styloid.
The needle, wire and sheath all come in the radial sheath kit (for example Terumo Glidesheath Slender). Your lab uses one of two techniques:
- Anterior wall: bare 21-gauge metal needle, about 4 cm long, at 30 to 45 degrees. Stop as soon as bright red blood pulses out of the hub, and hold the needle still.
- Through and through: a 20- or 22-gauge plastic cannula over a needle (like an IV catheter) goes through both walls. Take out the inner metal needle, then pull the plastic cannula back very slowly until blood pulses out. Hold it still.
Mini guidewire through the needle
The mini guidewire is short (about 45 cm) and thin, with a soft straight tip; it only holds the track for the sheath, and is too thin to carry a catheter. Thread it through the needle or cannula. It should slide with almost no resistance. Advance it until only enough is left outside to hold it and load the sheath.
Needle out, wire stays
Hold the wire at the skin with one hand and slide the needle back off the wire's back end with the other. If your lab does it, make a small skin nick beside the wire.
Sheath and dilator over the wire
Thread the wire's back end into the dilator tip and slide the sheath down the wire to the skin. Before the sheath enters the skin, the wire's back end must be coming out of the back of the dilator, with you holding it. Then advance sheath and dilator together, all the way to the hub.
A sheath's French size is the largest catheter it takes: a 6 French sheath takes a 6 French catheter. "Slender" sheaths have a thinner wall, so a 6 French Slender sheath is about as wide on the outside as a standard 5 French sheath, which matters in a small radial artery.
Dilator and wire out, sheath stays
Unlock the dilator from the sheath and pull the dilator and wire out together.
Femoral3B. Femoral access
Find the target on fluoro
Feel the pulse, then mark the middle of the femoral head on fluoro with a clamp on the skin. Find the common femoral artery with ultrasound if your lab uses it (most do). The skin crease is not a reliable landmark.
Micropuncture splits it into two stages:
1. Find the artery and make a small hole.
Using a 21-gauge needle + 0.018 inch wire.
If: the wire runs the wrong way on fluoro, or the femoral angiogram shows the stick is above the inferior epigastric artery or below the bifurcation, pull everything out and hold pressure (a 21-gauge hole usually seals easily).
2. Upsize from there.
Insert the micropuncture introducer (with its 3 Fr dilator inside) over the 0.018 wire.
Then remove the dilator and the 0.018 wire.
Then insert the 0.035 inch wire.
Then insert the femoral sheath (with its own dilator) over that.
Local anaesthetic
Over the target, raise a skin wheal of 1% lidocaine, then advance the needle along the track you will use and infiltrate down toward the artery, 10 to 15 mL in total. Pull back on the syringe before each injection, so none goes into a vessel. Some labs nick the skin with a scalpel now; others after the wire is in.
Micropuncture needle in
The micropuncture needle is often echogenic (textured to show up on ultrasound). Advance at about 45 degrees toward the target until blood pulses out of the hub. Stop and hold the needle still.
0.018 inch wire through the needle
Thread the wire through the needle, then check its course on fluoro: it should run up along the spine, not off laterally or into a small branch.
Needle out
Hold the wire at the skin and slide the needle off its back end. Compress lightly.
Introducer and dilator over the wire
Thread the wire's back end into the dilator tip , hold the wire where it comes out the back, and advance the dilator into the artery to its hub.
Dilator and 0.018 wire out
Unlock the inner dilator and pull it out with the 0.018 wire. Many attendings shoot a femoral angiogram now, with a small contrast injection through the introducer in an ipsilateral oblique view; others do it later through the sheath sidearm.
0.035 inch wire through the introducer
Check on fluoro that it runs up along the spine.
Introducer out
Hold the wire and slide the introducer off. Compress.
Sheath and dilator over the wire
Thread the wire's back end into the dilator tip , hold the wire where it comes out the back, and advance sheath and dilator together to the hub.
Dilator and wire out, sheath stays
Then flush the sidearm: step S1 below. Keep a hand on the sheath until it is secured.
Both: flush the sheath
Flush the sheath
The sheath's sidearm ends in a white stopcock. On this kind, the long lever (often marked OFF) points at the port that is closed; the other two ports are connected. Its three ports: the tubing to the sheath (the patient), the syringe port opposite it, and an uncapped side port at 90 degrees to both. At rest the OFF lever points at the patient. Radial and femoral sheaths are flushed the same way.
- With OFF at the patient, attach a fresh 10 mL syringe of heparinized saline to the syringe port.
- Turn 180 degrees: OFF at the syringe. The sheath now connects to the side port. Let blood run back out of the side port for a moment. That clears air and stagnant blood without it going near the syringe.
- Turn 90 degrees: OFF at the side port. The syringe now connects to the sheath. Draw back a little, until you see some blood in the syringe: the line is continuous and free of air.
- Flush forward into the sheath.
- Turn 90 degrees back: OFF at the patient. Keep pushing: saline now goes out of the side port and clears the blood from it. Leave the last mL in the syringe.
Practice: flush the sheath
The artery is on the left, the stopcock and syringe toward you on the right. Work through the flush. Do it with the controls below the drawing; with Show next step ticked (at the bottom), the control you need next glows.
Radial cocktail
Give it through the sidearm: with OFF at the side port, the syringe connects to the sheath; turn OFF back to the patient afterwards. A common version: verapamil 2.5 mg, nitroglycerin 100 to 200 mcg, and heparin (often 5,000 units or about 50 units/kg for a diagnostic case). Draw blood into the syringe to dilute it, inject slowly, and warn the patient that it will burn. Secure the sheath the way your lab does.
4. The diagnostic run: plan, and catheter up to the aorta
Pick one. Sections 4 to 8 then show only that access's sizes and steps. Until you pick, both are shown and tagged.
A standard diagnostic left heart cath runs in this order. Each catheter goes up to the ascending aorta the same way (steps C1 to C6), is connected and zeroed once (section 5), and is exchanged over the J-wire (section 7).
| Step | What you use | Where |
|---|---|---|
| Sheath | Radial6 French Glidesheath Slender, 10 or 16 cm. Heparin went in with the radial cocktail.Femoral6 French sheath, 10 or 11 cm. Usually no heparin for a diagnostic femoral case; the attending decides. | Radial3AFemoral3B |
| Wire | 0.035 inch J-wire, 150 cm, for every catheter.Radial Some attendings exchange over a 260 cm exchange-length wire from the radial (section 7). | 4 |
| 1. Left coronary | RadialJL3.5, 5 or 6 French, 100 cm (most attendings). One attending starts with a universal catheter (Tiger) that does both coronaries.FemoralJL4, 5 or 6 French, 100 cm. | 6 |
| 2. Right coronary | JR4, 5 or 6 French, 100 cm.Radial Skipped if the Tiger engaged both. | 7 |
| 3. LV and aorta | Angled pigtail, 5 or 6 French, 110 cm. LVEDP in most cases. LV gram and aortogram only when indicated. | 8 |
| Out and closure | RadialCompression band (TR Band).FemoralManual compression or a closure device. | 9 |
A catheter's French size must be no larger than the sheath's: 5 or 6 French catheters go through a 6 French sheath. Ask the attending which size before you flush.
Load the J-wire into the catheter
First catheter: RadialJL3.5 (or the Tiger, if your attending starts with a universal catheter), 5 or 6 French, 100 cm.FemoralJL4, 5 or 6 French, 100 cm.
Flush the catheter until saline drips from its tip. Wipe the 0.035 inch, 150 cm J-wire wet. Straighten the J with one hand: grip the shaft with your middle, ring and little fingers, and pinch the wire with your thumb and index just behind the J. Pull the two grips apart; the stretch straightens the J tip beyond your thumb and index. Keep it stretched and feed the straight tip into the catheter hub. Push the wire through. Stop with the wire tip just inside the catheter tip.
Catheter and wire into the sheath
Hold the catheter 3 to 5 cm from the sheath entrance, and push catheter and wire in together, in short strokes, until both are a few centimeters inside the sheath. The wire tip stays just inside the catheter tip while they enter the sheath; the wire only goes ahead in the next step.Radial The arm is on a board: keep the rest of the catheter flat on the drape, not hanging off the edge, so it does not pull back out.
Wire leads up to the ascending aorta
RadialHold the catheter still and advance the wire alone under fluoro. Watch the tip at the elbow and at the shoulder. At the shoulder it should turn down into the ascending aorta. It often drops into the descending aorta instead: pull it back into the subclavian, ask the patient to take a deep breath and hold it (that straightens the angle), and advance again. The attending may turn the catheter to point the wire.
FemoralHold the catheter still and advance the wire alone under fluoro, up the iliac and the abdominal aorta. Watch the tip, not the shaft. Over the arch it goes into the ascending aorta toward the valve.
Catheter follows the wire
The catheter tip never passes the wire tip.Radial In a tortuous subclavian the catheter may not follow around the turn. Another deep breath often helps; if not, the attending may switch to a hydrophilic wire (Glidewire, 0.035 inch, 150 cm).Femoral Bring the catheter around the arch into the ascending aorta.
Wire out
Hold the catheter hub still and pull the wire out through the wet gauze, coiling it as it comes.
Aspirate the catheter and connect the manifold
The catheter hub has no stopcock. Put an empty syringe straight onto the hub, pull back until blood comes with no bubbles, take it off, and discard the blood. Let the hub drip while you bring over the manifold's red rotating adapter, and connect wet to wet. First catheter only: connect and zero next (section 5).
5. Connect catheter to manifold and zero
Zeroing
With the catheter connected, the manifold still has to be zeroed before the pressure means anything. On your manifold the transducer sits on port 1 with its own small stopcock on top.
- Check the transducer cable has been handed off the table and plugged into the monitor.
- Position the transducer at mid-chest height (the phlebostatic axis).
- Port 1 right: the transducer is cut off from the catheter.
- Transducer stopcock up: the transducer is open to air.
- Press ZERO on the monitor. The reading goes to 0.
- Transducer stopcock back to right (closed to air).
- Home: down, right, right. The aortic pressure appears.
Re-zero if the table height changes.
SimulatorPractice: connect, zero, go home
Starts with a primed manifold and the catheter waiting in the aorta. Now connect it, zero, and go home. Do it with the controls below the drawing; with Show next step ticked (at the bottom), the control you need next glows.
6. Left coronary: engage, check pressure, inject
Engage the left coronary and check the pressure
RadialJL3.5 from the right radial. The attending advances it toward the left sinus in a shallow LAO view. It often needs a gentle push with a small turn, and a deep breath, to drop into the left main. Coming down from the right subclavian, a catheter behaves about half a size larger than from the femoral; that is why radial starts with JL3.5 where femoral starts with JL4.
RadialTiger (universal), if that is your attending's choice. Advanced into the left sinus, it engages the left main with little or no rotation. It stays in for the right coronary too (section 7).
FemoralJL4 from the femoral. The attending advances it slowly in a shallow LAO view. With the wire out, the JL4 usually drops into the left main by itself as it is advanced. If its tip floats above the ostium and will not reach, the next size up (JL5); if it folds or points down, the next size down (JL3.5).
Compare the tracing with the aortic pressure you recorded. If it damps or ventricularizes, say so out loud and do not inject: the tip is against the wall or there is ostial disease, and the attending will reposition. If it is normal, a small test injection confirms position, then the views.
Load, inject, go home
- Load: from home, turn port 3 up and pull back slowly. Port 1 stays down, so you keep watching pressure.
- Tip the syringe down and tap so bubbles rise to the plunger. If there is a lot of air: port 3 right, port 2 up, syringe tip up, push the air to the waste bag, port 2 right, reload.
- Inject: right, right, right. The pressure trace goes flat while you inject; that is expected.
- Inject with the tip down: a smooth push, commonly 6 to 10 mL for the left coronary. Never empty the syringe; leave the last few mL.
- Home: down, right, right. Check the tracing before the next injection.
SimulatorPractice: one injection
Starts at home, catheter engaged and zeroed. Now load contrast, inject, and go back home. Do it with the controls below the drawing; with Show next step ticked (at the bottom), the control you need next glows.
Aspirate through the manifold
When blood has sat still in the catheter, or the trace looks damped from a clot or bubble, aspirate through the manifold before the next injection: right, right, right, pull until blood comes with no bubbles, then port 2 up and push it into the waste bag, then home.
SimulatorPractice: aspirate and discard
Starts at home with the catheter connected. Now aspirate, send the blood to waste, and go home. Do it with the controls below the drawing; with Show next step ticked (at the bottom), the control you need next glows.
Left coronary views
Usually five or six views. Common order and what each shows:
| View | Best for |
|---|---|
| RAO caudal | Left main, proximal LAD, circumflex and OMs |
| AP caudal | Left main, proximal circumflex |
| LAO caudal ("spider") | Left main bifurcation, proximal LAD and circumflex |
| AP cranial | Mid and distal LAD, diagonals |
| RAO cranial | Mid and distal LAD, diagonal origins |
| LAO cranial | LAD and diagonals separated, septals |

7. Exchange and right coronary
RadialTiger: no exchange. After the left views the attending pulls back slightly out of the left main and rotates clockwise; the tip drops into the right coronary. Go to X5. If it will not engage the right, exchange to a JR4 as below.
Wire out past the catheter tip
The attending disengages the catheter. Disconnect it from the manifold. Reinserting the J-wire: re-wet the J-wire, straighten the tip (pinch and pull), feed it into the catheter end, and advance under fluoro until the J tip emerges from the catheter tip in the ascending aorta.
RadialIf your attending uses a 260 cm exchange-length wire for radial exchanges, this is where it goes in. It is long enough to hold at its back end while the whole catheter comes off, and it stays in the ascending aorta, so the next catheter does not have to find its way around the subclavian again.
Pin the wire, pull the catheter
Hold the wire still at the catheter end and pull the catheter back.
Grab the wire at the sheath
As you pull the catheter back, once the wire is exposed between the catheter tip and the sheath, grab the wire there.
Old catheter off, JR4 on
Wipe the wire as the old catheter comes off. Thread the wire's back end into the JR4's tip , and slide the catheter on. Keep going until the wire emerges from the catheter end, then hold the wire there like a rail; advance the JR4 into the sheath, and then let the wire begin leading as you advance back up to the aorta. Then wire out , aspirate the hub, connect the manifold, and go home. No need to re-zero.
Engage the right coronary and inject
Bring the catheter to just above the valve in the LAO view, then pull back slightly while rotating it clockwise, about 90 to 180 degrees. The tip turns toward the right sinus and drops into the RCA ostium.
RadialFrom the radial, torque takes longer to reach the tip. The attending turns slowly and lets the tip catch up; turned too fast, it whips past the ostium.
Check the pressure before each injection, exactly as for the left. Injections are smaller: commonly 4 to 6 mL.
| View | Best for |
|---|---|
| LAO | Proximal and mid RCA |
| RAO | Mid RCA, PDA length |
| AP cranial (or LAO cranial) | Crux, PDA and posterolateral branches |
8. Pigtail: LVEDP, LV gram, aortogram
LVEDP. Measured in most diagnostic cases. It gives the filling pressure before more contrast or fluid goes in. Skipped when the valve should not be crossed (see below).
LV gram (always with a pigtail). Do it when:
- LV function is unknown: no recent echo, or the echo images are poor
- Wall motion or mitral regurgitation needs assessing and the echo did not answer it
- The attending wants to match wall motion to the coronary findings
Aortogram (pigtail in the aortic root). Do it when:
- Aortic regurgitation needs grading and the echo did not answer it
- Bypass grafts or an anomalous coronary will not engage, to show where they arise
- The aortic root or ascending aorta needs assessing (dilation) and no CT or MRI already shows it
Skip the LV gram, or ask first, when:
- A recent echo already answers the question
- Contrast is limited by kidney function: an LV gram uses about 30 to 40 mL
- LVEDP is very high, or the patient is in decompensated heart failure: the contrast load can tip them into pulmonary edema
- There is a known LV thrombus
Do not cross the valve with a mechanical aortic valve. In severe aortic stenosis the attending crosses only if the gradient is needed, with a straight wire. With left bundle branch block, the catheter can bump the right bundle and cause complete heart block: know where temporary pacing is.
Exchange to the pigtail
Exchange as in section 7 to an angled pigtail, 5 or 6 French, 110 cm. To load it, straighten the loop a little with your fingers so the end hole points at the wire, and load it with the fingertip technique . Every LV gram and aortogram is done with a pigtail: the loop keeps the tip off the ventricular wall, and the side holes spread the contrast. Leave the tip in the ascending aorta, just above the aortic valve. Wire out , aspirate, connect, home.
RadialThe pigtail comes down the ascending aorta toward the valve the same way. In a tall patient, or with a long arm route, 110 cm may not reach; ask for a longer one.
Clear contrast from the line
Contrast in the line damps the pressure. Port 2 up, pull 5 to 10 mL of saline, port 2 right, then right, right, right and push it through, then home.
Cross the valve, record LVEDP
The attending crosses the aortic valve into the LV with the pigtail. Watch the monitor for ectopy. Record LV pressure. LVEDP is read at end diastole: just after the small a wave, right before the steep upstroke of systole.
LV gram (only if indicated)
- Disconnect the pigtail from the manifold. Connect the power injector line wet to wet, with no air in the connection.
- View: usually RAO 30 degrees (some add LAO 45 to 60 for the septum and lateral wall).
- The tech sets the injector. Common settings are about 30 to 36 mL at 10 to 15 mL/s; your lab's defaults rule.
- Watch for ectopy during the injection: PVC beats make that part of the gram hard to read.
- Reconnect the manifold, home. The attending may want a repeat LVEDP.
Pullback
The pigtail is pulled back from the LV across the valve into the aorta while the pressure is recorded. A drop in systolic pressure as it crosses the valve (a gradient) suggests aortic stenosis. A drop while still inside the LV suggests obstruction below the valve.
Aortogram (only if indicated)
- Pigtail tip in the aortic root, 2 to 3 cm above the valve (above the sinuses), so contrast fills the root without going through the valve.
- Power injector connected wet to wet. Common settings are about 40 mL at 20 mL/s; your lab's defaults rule.
- The attending picks the view, often LAO, to open out the root and show any regurgitant jet into the LV.
9. Catheter out and closure
Catheter out
Ask whether the attending wants the wire back in before the catheter comes out. Many do for curved catheters coming down the arm, so the tip does not catch the vessel wall. If yes: wire in until its tip reaches the catheter tip, then pull catheter and wire out together, under fluoro if there is resistance. The sheath stays until closure.
Radial: compression band
- If your band's instructions say so, pull the sheath back 2 to 3 cm.
- Place the band so its marker sits over the arterial puncture, a few millimetres proximal to the skin entry. Close the strap.
- Inflate the band (for example Terumo TR Band) with its own syringe, commonly 15 to 18 mL of air, per your unit's protocol, while you slowly pull the sheath out.
- Let air out slowly until a little blood appears at the site, then put 1 to 2 mL back until it stops. That is patent hemostasis: no bleeding, radial artery still open.
- Check: pulse oximeter on the thumb, compress the ulnar artery; a waveform means the radial is open.
Femoral: compression or closure device
Manual compression: the ACT usually needs to be below a set value (often 150 to 180 seconds). Find the pulse 1 to 2 cm above the skin entry, pull the sheath in one smooth motion, and press firmly with two or three fingers over the arterial puncture. Hold firm pressure, then ease gradually, usually 15 to 20 minutes in total. Check the site and the distal pulses.
Closure devices such as Angio-Seal (6 or 8 French: an anchor inside the artery and a collagen plug outside) or Perclose ProGlide (a suture across the puncture) need a femoral angiogram showing a suitable puncture site; follow the device's steps and the attending.
10. Problems to spot early
For each one: notice it, and say it out loud.
| What you see | What it might be |
|---|---|
| Wire or catheter won't advance up the arm; patient in pain | Radial spasm, loop, or anomaly |
| Pressure damps or ventricularizes after engagement | Catheter against the wall, or ostial stenosis |
| Contrast stays in the vessel wall after injection | Dissection |
| Slow or absent flow after stenting | No-reflow, dissection, or thrombus |
| Bradycardia, hypotension, nausea, sweating | Vasovagal reaction |
| Contrast outside the vessel | Perforation |
| Hives, wheeze, hypotension after contrast | Contrast reaction |
| Hypotension with back or flank pain after femoral access | Retroperitoneal bleed |
| Sudden ST elevation after an injection, bubbles seen | Air embolism |